A unique elastase in human blood platelets.

A unique elastase in human blood platelets.

Previous investigations suggested that elastolytic activity found in platelets could be due to contamination by neutrophil elastase. In the present study, the lysate of blood platelets free of detectable neutrophils was examined for elastase-like activity using tertiary-butyloxycarbonyl (tBOC)-ala-ala-pro-ala-aminomethyl coumarin (I), tBOC-ala-ala-pro-val-aminomethyl coumarin (II), and succinyl...

Plasmalogen in human blood platelets.

Plasmalogens have now been identified in a wide variety of organisms (l-3). In studies previously reported, plasmalogens were identified and roughly quantitated (4) in human platelet phosphatides. The present report concerns a precise determination of’plasmalogens in human blood platelets with the use of techniques not previously available. An evaluation of the possible role of plasmalogens in ...

Phospholipase D in human blood platelets

Induction of apoptosis in human tumor cell lines by platelets

Introduction: It has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. The effect of platelets on the induction of apoptosis in tumor cells is largely unknown. Materials and methods: To investigate this effect, two human hematologic cell lines, K562 and Daudi, were independently faced with unstimulated and thromb...

Sialic Acid of Human Blood Platelets * MORTON

Sialic acid has been demonstrated in the blood platelets of man and other species (1, 2), but its function in these elements is unknown. Jerushalmy, Kohn, and de Vries (3) and others (4, 5) have shown that Myxoviruses are adsorbed to and eluted from blood platelets. Bacterial neuraminidase, which liberates free sialic acid by cleavage of the a-ketosidic linkage between terminal sialic acid and ...